One Article Review
| Source |  Errata Security |
|---|---|
| Identifiant | 1964696 |
| Date de publication | 2020-10-08 21:44:25 (vue: 2020-10-09 02:13:22) |
| Titre | Factcheck: Regeneron\'s use of embryonic stem cells |
| Texte | This week, Trump's opponents misunderstood a Regeneron press release to conclude that the REG-COV2 treatment (which may have saved his life) was created from stem cells. When that was proven false, his opponents nonetheless deliberately misinterpreted events to conclude there was still an ethical paradox. I've read the scientific papers and it seems like this is an issue that can be understood with basic high-school science, so I thought I'd write up a detailed discussion.The short answer is this:The drug is not manufactured in any way from human embryonic tissues.The drug was tested using fetal/embryonic cells, but ones almost 50 years old, not new ones.Republicans want to stop using new embryos, the ethical issue here is the continued use of old embryos, which Republican have consistently agreed to.Yes, the drug is still tainted by the "embryonic stem cell" issue -- just not in any of the ways that people claim it is, and not in a way that makes Republicans inconsistent.Almost all medical advances of the last few decades are similarly tainted.Now let's do the long, complicated answer. This starts with a discussion of the science of Regeneron's REG-COV2 treatment.A well-known treatment that goes back decades is to take blood plasma from a recently recovered patient and give it to a recently infected patient. Blood plasma is where the blood cells are removed, leaving behind water, salts, other particles, and most importantly, "antibodies". This is the technical concept behind the movie "Outbreak", though of course they completely distort the science.Antibodies are produced by the immune system to recognize and latch onto foreign things, including viruses (the rest of this discussion assumes "viruses"). They either deactivate the virus particle, or mark it to be destroyed by other parts of the immune system, or both.After an initial infection, it takes a while for the body to produce antibodies, allowing the disease to rage unchecked. A massive injection of antibodies during this time allows the disease to be stopped before it gets very far, letting the body's own defenses catch up. That's the premise behind Trump's treatment.An alternative to harvesting natural antibodies from recently recovered patients is to manufacture artificial antibodies using modern science. That's what Regeneron did. An antibody is just another "protein", the building blocks of the body. The protein is in the shape of a Y with the two upper tips formed to lock onto the corresponding parts of a virus ("antigens"). Every new virus requires a new antibody with different tips.The SARS-COV-2 virus has these "spike" proteins on it's surface that allow it to invade the cells in our lungs. They act like a crowbar, jamming themselves into the cell wall, then opening up a hole to allow the rest of the virus inside. Since this is the important and unique prote |
| Envoyé | Oui |
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